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Amgen Bone Health Mentoring Program
Monday, October 15, at 11:30am – 2:30pm ◼ Ruth Chris, Minneapolis, MN
1038 PTH/PTHrP Receptor Signaling in Osteocytes
Regulates Anabolic and Catabolic Bone Responses to
PTH by Modulating Bone Remodeling via Sclerostin and
RANKL Expression.
Saini V, Fulzele K, Barry K, et al.
Session: Concurrent Oral Session 07: Osteocytes ◼
Weekday, October 13, 02:30 PM - 02:45 PM ◼ Room
101C/Minneapolis Convention Center
Objective Abstract Information Additional Notes from
Methods Poster/Presentation*
▪ On the premise that osteocytes may
partially mediate the anabolic effects Strengths, Weaknesses, Key
of PTH, this study investigated the role Points
of PPR signaling in osteocytes.
▪ Mice lacking PPR in osteocytes
(OcyPPRKO) were generated;
littermates carrying the floxed PPR
alleles were used as controls.
▪ For anabolic regimen, 8-week-old
female mice were injected with 80
mg/kg/day hPTH (1-34) for 4 weeks
whereas for catabolic treatment, 13-
week-old male mice were infused for 2
weeks with 100 mg/kg/day.
▪ Outcomes were analyzed using mCT
and histomorphometric techniques.
* Assignment notes will be collected at the Amgen Mentoring Program Debrief Meeting. Hardcopy or Electronic versions are acceptable
