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Amgen Bone Health Mentoring Program

Monday, October 15, at 11:30am – 2:30pm ◼ Ruth Chris, Minneapolis, MN

1028 Effects of Odanacatib on the Distal Radius and

Tibia in Postmenopausal Women: Improvements in

cortical geometry and estimated bone strength.

Papp A, Cheung A, Majumdar S, et al.

Session: Concurrent Oral Session 05: John H. Carsten's
Memorial Session for Osteoporosis Treatment ◼
Saturday, October 13, 10:15 AM - 10:30 AM ◼

Auditorium-Main/Minneapolis Convention Center

Abstract Information Additional Notes from
Poster/Presentation*

Results ▪ Percent change in LS BMD from baseline Updated/Additional
Data, Key Takeaways
Conclusions at 1 year was greater for ODN as
Implications
for Canadian compared to placebo (p<0.001).
▪ After 2 years, ODN as compared to
Practice
placebo was associated with greater

improvements in
o trabecular, and cortical volumetric

BMD;
o cortical thickness;
o estimated strength (failure load) of

the distal radius
o At the radius, ODN attenuated

cortical porosity increases
▪ Changes in vBMD and cortical thickness

were similar at the distal tibia and radius.
▪ Safety and tolerability were similar

between treatment groups.

▪ ODN as compared to placebo improves
cortical and trabecular density and
cortical thickness of the distal radius and
tibia. ODN also improves bone strength in
the distal radius.

Discussion Points, Key Takeaways