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Amgen Bone Health Mentoring Program
Monday, October 15, at 11:30am – 2:30pm ◼ Ruth Chris, Minneapolis, MN
FR0169 Bone Healing Enhancement through Inhibition
of Sclerostin by Monoclonal Antibody in Rat Osteotomy
Model.
Suen P, Yixin H, Chow D, et al.
Session:Welcome Reception and Plenary Poster
Session◼ Friday , October 12, 05:45 PM - 07:00 PM◼
Discovery Hall-Hall B/Minneapolis Convention Center
Results Abstract Information Additional Notes from
Conclusions Poster/Presentation*
▪ At weeks 3, 6 and 9, Scl-Ab group as
compared to vehicle had a Updated/Additional Data,
significantly higher callus volume Key Takeaways
fraction and BMD (p<0.01)
▪ At weeks 3 and 6, Scl-Ab group had
increased callus vascularization
▪ H&E and safranin O staining
indicated more bony tissue in
calluses at week 3 in Scl-Ab group.
▪ Ultimate load, stiffness and energy to
failure were higher in the Scl-Ab
group.
▪ Scl-Ab enhances bone healing along
with increased bone formation, bone
mass and bone strength in rat
models of osteotomy,
Implications Discussion Points, Key Takeaways
for Canadian
Practice
