Page 6 - Slide 1
P. 6
Amgen Bone Health Mentoring Program
Monday, October 15, at 11:30am – 2:30pm ◼ Ruth Chris, Minneapolis, MN
FR0169 Bone Healing Enhancement through Inhibition
of Sclerostin by Monoclonal Antibody in Rat Osteotomy
Model.
Suen P, Yixin H, Chow D, et al.
Session:Welcome Reception and Plenary Poster
Session◼ Friday , October 12, 05:45 PM - 07:00 PM◼
Discovery Hall-Hall B/Minneapolis Convention Center
Abstract Information Additional Notes from
Poster/Presentation*
Objective ▪ This report presents the effects of
Methods sclerostin monoclonal antibody (Scl- Strengths, Weaknesses, Key
Ab) on fracture repair in rat femur Points
open fracture.
▪ A day after transverse osteotomy at
the mid-shaft of right femur, 90 male
SD rats were administered Scl-Ab III
(s.c. injection, 25 mg/kg, 2 times per
week) or vehicle for 3, 6 or 9 weeks.
▪ Fracture repair was analyzed using
mCT, mCT-based angiography,
histological methods and 4-point
mechanical testing.
* Assignment notes will be collected at the Amgen Mentoring Program Debrief Meeting. Hardcopy or Electronic versions are acceptable
